Wednesday, February 23, 2011

Laron Syndrome - Imunity to Cancer?

I found this article about Ecuadorians with Laron Syndrome really fascinating.  It talks about how those with this syndrome have stunted growth but at the same time, the genes that cause the syndrome give these people immunity to cancer and diabetes.  This was first discovered by a scientist studying one hundred or so Ecuadorians with this condition who noticed that not one of them had ever had cancer or diabetes although the area where they all lived had high numbers of cancer and diabetes victims.  After some studies he finally learned why this was happening.  He soon discovered also that this condition first originated in Ecuador when some European carried it over many years ago.  I am amazed by all of this and the first thing that came to mind after reading this was if somehow people who don’t have the syndrome could use these genes to prevent cancer and diabetes.  This syndrome happens when there is a mutation in a certain gene that codes for growth hormone receptor and eventually produces lower amounts of IGF1, a growth factor. Because high levels of IGF1 can lead to cancer and diabetes, these low levels result in immunity.  I think it would be so great if we could cause this mutation in the gene in all humans so that everybody could be immune to these diseases.  All it takes is some research to see how this gene mutates and if it would be possible to simulate this mutation in those without the syndrome or if there is another way to decrease the levels of IGF1 while at the same time not resulting in stunted growth.  Specifically, there is a case of a young Ecuadorian that has Larons while her sisters do not even though they carry the same gene. It sounds like it is really difficult to figure out about how this could lead to prevention of cancer and diabetes, but if such a discovery is made, so many lives would be saved.   Tests and experiments should be made very carefully though because based on this article, it sounds like badly done tests could be very harmful to the body.  Tests are already being carried out in mice to test the effects of this condition and lack of IGF1.  In the future, drugs that cause this mutation of the gene could become common and lead to at least major prevention if not a cure.

http://abcnews.go.com/video/playerIndex?id=6303784

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